Flexible Backbone Assembly and Refinement of Symmetrical Homomeric Complexes

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Homomeric protein complexes: evolution and assembly.

Homo-oligomeric protein complexes are functionally vital and highly abundant in living cells. In the present article, we review our current understanding of their geometry and evolution, including aspects of the symmetry of these complexes and their interaction interfaces. Also, we briefly discuss the pathway of their assembly in solution.

متن کامل

Self-assembly and evolution of homomeric protein complexes.

We introduce a simple "patchy particle" model to study the thermodynamics and dynamics of self-assembly of homomeric protein complexes. Our calculations allow us to rationalize recent results for dihedral complexes. Namely, why evolution of such complexes naturally takes the system into a region of interaction space where (i) the evolutionarily newer interactions are weaker, (ii) subcomplexes i...

متن کامل

The self-assembly and evolution of homomeric protein complexes

Gabriel Villar, Alex W. Wilber, Alex J. Williamson, Parvinder Thiara, Jonathan P. K. Doye, ∗ Ard A. Louis, Mara N. Jochum, Anna C. F. Lewis, and Emmanuel D. Levy Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford, OX1 3QZ, United Kingdom Rudolf Peierls Centre for Theoretical Physics, University of Oxford, 1 Keble Road, Oxford, ...

متن کامل

Flexible Refinement

To help make refinement more usable in practice we introduce a general, flexible model of refinement. This is defined in terms of what contexts an entity can appear in, and what observations can be made of it in those contexts. Our general model is expressed in terms of an operational semantics, and by exploiting the well-known isomorphism between state-based relational semantics and event-base...

متن کامل

FiberDock: a web server for flexible induced-fit backbone refinement in molecular docking

Protein-protein docking algorithms aim to predict the structure of a complex given the atomic structures of the proteins that assemble it. The docking procedure usually consists of two main steps: docking candidate generation and their refinement. The refinement stage aims to improve the accuracy of the candidate solutions and to identify near-native solutions among them. During protein-protein...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Structure

سال: 2019

ISSN: 0969-2126

DOI: 10.1016/j.str.2019.03.014